ADARx Pharmaceuticals
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We are a messenger RNA base-editing company. Our mission is to discover and develop cutting-edge genetic therapeutics that precisely target and edit single point mutations on RNA transcripts to enable production of desired proteins.

Science of RNA Editing

RNA editing is a process through which a nucleotide sequence specified in the genomic template is modified to produce a different nucleotide sequence in the transcript.

One of the most common RNA editing naturally occurred is the deamination of adenosine (A) to inosine (I), which is catalyzed by enzymes called adenosine deaminases acting on RNA (ADARs). These enzymes are ubiquitously expressed in human tissues. The edited site (I) is recognized as G instead of A during translation.

By recruitment of endogenous ADARs, RNA editing therapeutics can precisely edit single point mutations, from A to G on messenger RNA to enable production of desired proteins. RNA editing therapeutics hold great promise to provide medicines for current undruggable diseases.