| Program/Technology | Target | Indication | Discovery | IND-enabling | Phase 1 | Phase 2 | Phase 3 | Ownership/ Collaboration |
|---|---|---|---|---|---|---|---|---|
| Hepatic | ADX-038 (Agazisiran) | CFB | Renal (IgAN, C3G) |  | ||||
ADX-038 (Agazisiran), Renal (IgAN, C3G) Close | ||||||||
| ADX-038 (Agazisiran) | CFB | GA | | |||||
ADX-038 (Agazisiran), GA Close | ||||||||
| ADX-038 (Agazisiran) | CFB | PNH | | |||||
ADX-038 (Agazisiran), PNH Close | ||||||||
| ADX-324 (Onvuzosiran) | PKK | HAE | | |||||
ADX-324 (Onvuzosiran), HAE Close | ||||||||
| ADX-626 | FXI | Thrombosis | | |||||
ADX-626, Thrombosis Close | ||||||||
| Extrahepatic | ADX-077 | Undisclosed Extrahepatic | Obesity | | ||||
ADX-077, Obesity Close | ||||||||
| ADX-199 | APP | Neuro-degeneration | | |||||
ADX-199, Neuro-degeneration Close | ||||||||
| Undisclosed | Extrahepatic | CNS (multiple) |  | |||||
Undisclosed, CNS (multiple) Close | ||||||||
| Undisclosed | Extrahepatic | Immunology | | |||||
Undisclosed, Immunology Close | ||||||||
| Undisclosed | Extrahepatic | Oncology | | |||||
Undisclosed, Oncology Close | ||||||||
| Hepatic | ||||
| Discovery | IND-enabling | Phase 1 | Phase 2 | Phase 3 |
ADX-038 (Agazisiran) Target: CFB | Indication: Renal (IgAN, C3G) Ownership/ | ||||
ADX-038 (Agazisiran) Target: CFB | Indication: GA Ownership/ | ||||
ADX-038 (Agazisiran) Target: CFB | Indication: PNH Ownership/ | ||||
ADX-324 (Onvuzosiran) Target: PKK | Indication: HAE Ownership/ | ||||
ADX-626 Target: FXI | Indication: Thrombosis Ownership/ | ||||
| Extrahepatic | ||||
| Discovery | IND-enabling | Phase 1 | Phase 2 | Phase 3 |
ADX-077 Target: Undisclosed Extrahepatic | Indication: Obesity Ownership/ | ||||
ADX-199 Target: APP | Indication: Neuro-degeneration Ownership/ | ||||
Undisclosed Target: Extrahepatic | Indication: CNS (multiple) Ownership/ | ||||
Undisclosed Target: Extrahepatic | Indication: Immunology Ownership/ | ||||
Undisclosed Target: Extrahepatic | Indication: Oncology Ownership/ | ||||
APP = Amyloid-β Precursor Protein; C3G = Complement 3 Glomerulopathy; CFB = Complement Factor B; CNS = Central Nervous System/Neuroscience; FXI = Factor XI; GA = Geographic Atrophy; HAE = Hereditary Angioedema; IgAN = IgA Nephropathy; PKK = Prekallikrein; PNH = Paroxysmal Nocturnal Hemoglobinuria
